Title: Rapid Treatment Guidance for Antibiotic-Resistant Disease at the Point of Care
About: This study will test a recently developed platform for characterizing bacterial infection at the POC for allowing clinicians to more effectively prescribe antibiotic therapies and to chart the spread of antibiotic resistance e.g., extended-spectrum beta-lactamase (ESBL). This platform will be validated on clinical specimens in Chiang Mai, Thailand.
Title: Optical Imaging Guided Resection and Photodynamic Therapy of Glioma with Targeted Photoactivable Agents
About: This application proposes to build an advanced nanoparticle for treatment of glioblastoma (GBM) that will combine diagnostic capabilities using fluorescence and photoacoustic (PA) imaging and therapeutic capabilities with photodynamic therapy (PDT) and simultaneous delivery of a receptor tyrosine kinase inhibitor known to interact synergistically with PDT.
Title: Bioluminescence-activated photodynamic therapy of breast cancer
About: The proposed research will develop and test novel photodynamic therapy (PDT) for killing cancer cells in the tumor margin and regional lymph nodes with minimal damage to normal tissues.
Title: Molecular Response and Imaging-based Combination Strategies for Optimal PDT
About: This project builds on recent advances in the understanding of cancer biology, in mechanisms of current and emerging therapies as well as the enormous progress made in imaging technologies, to propose new photodynamic therapy (PDT)-based combination treatments for pancreato-biliary and non-melanoma skin cancers.
Low-cost Enabling Technology for Image-guided Photodynamic Therapy (PDT) of Oral Cancers
About: This proposal aims to address the problem of oral cancer by using a low-cost adaptation of photodynamic therapy (PDT).
Support Completed Within the Past Five Years
Heterocellular 3-D Ovarian Tumor Arrays for Imaging and Mechanistic Combinations
About: The long-term goal of this research is to develop, integrate and validate key platform technologies to screen mechanism-based combination regimens with photodynamic therapy (PDT) for residual and recurrent OvCa. Heterocellular 3D printed tumor arrays that incorporate critical determinants of OvCa biology (endothelial and mesothelial cells with macrophages and fibroblasts) along with hyperspectral microscopy for simultaneous quantitative imaging of multiple biomarkers will provide exceptional insight into OvCa growth and treatment response on a high throughput platform.
Ovarian Cancer PDT: Multi-intracellular targeting and Image-guided Dosimetry
About: The long term goal is to develop, integrate and validate key platform technologies to combine quantitative fluorescence imaging for drug delivery monitoring and customized dosimetry with "Targeted Phototoxic Multi-Inhibitor Liposomes" (TPMILs) that selectively target and simultaneously block interconnected survival pathways associated with aggressive ovarian cancer.
Research to Develop and Apply Biophotonics to Military Medicine Needs.
About: The major goals of this project are to further research in areas of military medicine. Dr. Hasan’s project is “Rapid Fluorescence-Based Antibiotic Susceptibility Assay”.
Targeted Photoactivable Nanocells: Image-based Drug Delivery and Dosimetry in GBM
About: The major goal of this research is to develop a combination of drug delivery nanoconstructs with magnetic resonance-guided optical imaging for the treatment of glioblastoma multiforme.
Image-Guided Phototherapy to Prevent Ovarian Cancer Recurrence (through Boston University)
About: This proposal aims to reduce the high rate of ovarian cancer (OvCa) recurrence and mortality by monitoring and selectively destroying residual, microscopic tumors using a “theranostic” platform that integrates fluorescence microendoscopy and near-infrared phototherapy.
Image Guided PDT for Glioma Using Photoactivatable Nanocarriers
About: The first goal of this project is to develop new nano-compositions, including targeting entities that show preferential accumulation in Glioblastoma multiforme. The second objective of the project is to test these compositions in imaging and therapy to reinforce image-guided platforms for the treatment of cancer.
Point of Care Technology Research Center in Primary Care: “Rapid Fluorescence-Based Determination of Antibiotic Susceptibility”
About: The goals of this cooperative agreement are to create and facilitate clinically-driven point-of-care solutions that address critical areas of unmet need in primary care, including funding, testing and evaluating prototype performance in simulated clinical environments and clinical living laboratories, transitioning prototypes into commercially licensable or start-up company opportunities, and disseminating lessons learned and best practices in innovation methodology in collaboration with other NIBIB Point of Care Technology Research Centers.
Continued Studies on the Effect of Combining Quaternary Alkaloids and Chemotherapeutic(s) in an Orthotropic Pancreatic Cancer Mouse Model.
About: In this continuation phase of the project, the inhibitory synergism of the optical isomers of morphinan alkaloids in combination with other agents in the pancreatic cancer model will be elaborated.