Current Hasan Lab Members

 

Administrative Personnel

Laura Maddox

Administrative Coordinator

 

Laura earned her BA in International Relations and Latin American Area Studies with a focus on Cross-Cultural Communications from American University in Washington DC. She has worked in a variety of operations and managerial positions in medical devices, higher education, and public transportation. She is the Administrative Coordinator for Dr. Tayyaba Hasan and has been at the Wellman Center since 2021.
 

Emad Salman Shaikh, MD

Program Manager

 

Emad earned his medical degree from Pakistan and then did his training at the Weill Cornell Medical College-Qatar affiliated Hamad General Hospital in Doha, Qatar. He completed his Post-Doctoral Fellowship at Spaulding Rehabilitation Hospital, Harvard Medical School. He is currently earning a MPH degree at the Harvard T. H Chan School of Public Health.  Most recently, Emad was a Post-Doctoral Fellow at the MGH Liver Center. He is involved in the development and writing of protocols and management of IRB reviews and visits, as well as helping manage Grants within the lab. 

 

Current Lab Members

 

 

Zhiming Mai, PhD

Instructor

 

Zhiming earned his Ph.D. in Molecular Biology and Immunology from Louisiana State University School of Veterinary Medicine. Since then, he has been working at Harvard Medical School-Affiliated Hospitals for over 20 years and specializes as a cancer biologist.
His research interests focus on the investigation of photodynamic therapy-based combination treatments using preclinical animal models for certain human cancer with aims at the enhancement of the treatment specificity and efficacy.

Yanfang Feng, PhD

Instructor

 

Yanfang earned her BSc and MSc at Sichuan University and the National Institute for Communicable Disease Control and Prevention in China. She earned her PhD in Medical Microbiology from the University Of Amsterdam in the Netherlands. She has been with The Hasan lab in The Wellman Center for Photomedicine since 2017. Yanfang is a microbiologist with specialized training in molecular evolution and the epidemiology of antibiotic resistance in bacterial pathogens.
Her research focuses on the development of point-of-care diagnosis for antibiotic-resistant pathogens and the use of photodynamic therapy for antibiotic-resistant infections.

Mohammad Ahsan Saad, PhD

Instructor

 

Saad obtained his PhD in Nanomedicine from the Centre for Cellular and Molecular Biology (CCMB), India. With brief postdoctoral stints at CCMB and Cleveland Clinic, Saad joined the Hasan lab at the Wellman Center for Photomedicine in 2018. He is a biochemist with extensive experience in molecular biology, biophysics, and biomedical imaging.
His major research focus is the development of targeted constructs for imaging and treatment of oral and pancreatic tumors.

José Quilez-Alburquerque, PhD 

Research Fellow

 

Jose earned his BS at the Complutense University of Madrid, his Master of Drug Discovery at the University of Alcala, and his PhD in Organic Chemistry at the Complutense University of Madrid. He is a chemist with extensive experience in photochemistry, optical sensing, and organic synthesis.
Jose’s research focuses on the development of light activable liposomal-like nanostructures to co-deliver photodynamic priming and chemotherapeutics or antibiotics in pancreatic cancer or antibiotic-resistant infections respectively.

 

 
 
 

Fernanda Viana Cabral, DVM, PhD

Research Fellow

 

Fernanda earned her PhD in Biomedical Sciences from the Nuclear and Energy Research Institute, part of the University of São Paulo in Brazil. After a brief stint as a post-doc at St Andrews in the UK, the travel bug brought her to the Hasan Lab.  She is the winner of the prestigious and very competitive Thomas F Deutsch Fellowship in Biomedical Optics (jointly awarded from the Optica Foundation and MGH). She also has a patent application for Chitosan nanoparticles containing S-nitroso-mercaptosuccinic acid (S-nitroso-MSA) to treat cutaneous leishmaniasis.
Her research focus is on in vitro and preclinical trials using mouse models for drug evaluation for neglected diseases …

 

Nayab Tahir, PhD

Research Fellow

 

Nayab earned his PhD in Pharmaceutics from the Islamia University of Bahawalpur, Pakistan in 2018. His project was “Lipid-Polymer Hybrid Nanoparticulate Drug Delivery System Formulation Design nd Evaluation”. He  worked as a lecturer in the Pharmacy Faculty at the University of Sargodha Pakistan prior to winning the prestigious Fulbright Fellowship to study in the US for a year in our lab. 

 

 

Harrison Roberts

Research Technician

 

Harrison earned his BS in Biochemistry and Molecular Biology from Lyman Briggs College, part of Michigan State University. Harrison joined the Hasan Lab in July of 2022 and is now applying to medical school. He wants to become a physician, with interests in surgery and oncology.

Natalie Eidenschink

Research Technician

 

Natalie earned her BS in Biochemistry from The College of Saint Scholastica in MN and joined the Hasan Lab in June 2023. She plans to take 2 gap years here doing and will apply for MD-PhD programs in the future. Also a certified CNA, her interests in OB/GYN and Oncology will be valuable in her work in our lab.

Derek Allen

Research Technician

 
Derek earned his B.Eng in Biomolecular, Cellular, and Tissue Engineering from McGill University in Montreal, Canada; he subsequently joined the Hasan lab in June of 2023. Derek’s research background focuses on using optical techniques to design systems for probing and modifying cellular morphology and behavior. Derek is applying this experience to the Hasan Lab by working on PDT experiments involving in vitro and in vivo models of pancreatic cancer. He plans to pursue a Ph.D. in biomedical engineering.

Visiting Scientists

 

Jonathan (Jon) Celli, PhD

Visiting Scientist
 
Jonathan Celli is an Associate Professor of Physics, at the College of Science and Mathematics at the University of Massachusetts Boston as well as a Graduate Program Director there. Affiliated with Harvard Medical School as an Instructor in Dermatology since 2010, Jon is a longtime collaborator with the Wellman Center for Photomedicine.
 
Holding a dual appointment, his research is focused on problems at the intersection of physics and cancer biology, integrating a variety of custom imaging-based methodologies for quantitative analysis of tumor-microenvironment interactions, the role of extracellular matrix mechanics, and evaluation of photodynamic therapy (PDT) treatment response
 
Bryan Q. Spring, PhD
Visiting Scientist
 
Bryan Q. Spring is an Associate Professor of Biomedical Physics and an Affiliated Faculty of Bioengineering (Northeastern University, Boston), and a Visiting Scientist at the Wellman Center for Photomedicine (Massachusetts General Hospital and Harvard Medical School).
 
As an undergraduate NSF fellow, he contributed to characterizing one of the intricate photophysical parameters of Förster resonance energy transfer (FRET) under the guidance of Robert S. Knox (Department of Physics, University of Rochester, NY). His doctoral work with Robert M. Clegg (Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign) focused on developing fluorescence lifetime and quantitative FRET imaging. He developed patent pending technology for molecular imaging and selective treatment of cancer micrometastases during his postdoctoral fellowship in Tayyaba Hasan’s laboratory (Wellman Center for Photomedicine).
 
Since joining the faculty at Northeastern University in 2015, Prof. Spring received The NCI Transition Career Development Award (K22) as well as an award from the Smith Family Awards Program for Excellence in Biomedical Research. In 2021, he was selected as a Scialog Fellow for Advancing Bioimaging. 
 
Bryan’s research in the Hasan group focuses on fluorescence microendoscopy for minimally- invasive monitoring of treatment responses in mouse models of ovarian and pancreatic cancer.
 
Outside the laboratory, Prof. Spring practices meditation, calisthenics, and running, and he loves to travel in his spare time.
 

Edward Maytin, MD PhD

Visiting Scientist
 
Edward Maytin, MD, is Section Head of Molecular Dermatology in the Department of Dermatology, as well as a Staff Member in the Department of Biomedical Engineering at the Cleveland Clinic. He is also an Assistant professor of Chemistry and Biomedical Engineering at Cleveland State University and Assistant Professor in the Department of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University. 
 
A frequent collaborator with the Hasan Lab, Dr. Maytin’s research focuses on two thematic areas: (1) wound healing, and (2) skin cancer. For wound healing, we are interested in the role of the extracellular matrix in wound repair. A large carbohydrate molecule called hyaluronan is an abundant component of the matrix and also of the pericellular coats of fibroblasts, epithelial cells, and blood vessels; the addition of certain proteins to hyaluronan after injury appears to be critical for regulating inflammation and fibrosis in healing wounds. Understanding this regulation may provide new ideas for therapy of poorly healing wounds in diabetes.
 
For skin cancer, we are working to improve a skin cancer treatment called photodynamic therapy (PDT). PDT has two components: a porphyrin precursor that is selectively taken up into malignant cells and converted to porphyrin, and a strong light source that activates the porphyrin inside the cancer cells, producing oxygen free radicals and causing cell death. Under the proper conditions, PDT can also stimulate anti-tumor immunity. We have found that pretreatment with certain drugs and hormones (including methotrexate and Vitamin D) can lead to more porphyrin accumulation, more efficient cell killing upon exposure to light, and improved stimulation of anti-tumor immune mechanisms.

 

 
Shakir Khan, PhD
Visiting Fellow

 

Shakir Khan earned his PhD in Biotechnology from Aligarh Muslim University. Shakir is based out of Jon Celli’s lab at UMass Boston.
 
Currently, his post-doctorate work is investigating engineering design changes to make oral cancer Photodynamic Therapy (PDT) devices more user-friendly, cost-effective, and conducive to commercial development for point-of-care oral cancer PDT treatment. In addition to that, he is constructing and working on various in-vitro tissue models for the analysis of light dosimetry, methods of photosensitizers localization and fluorescence imaging. He also works on Curcumin nanoparticles for the application on clinical oral cancer (superficial lesions PDT).
 

Brian Pogue, PhD

Visiting Scientist
 
Brian Pogue is Professor of Medical Physics and Department Chair as well as Director of Graduate Programs for the Department of Medical Physics at the University of Wisconsin School of Medicine and Public Health.

 

His research focuses on Optics in medicine, biomedical imaging to guide cancer therapy; molecular guided surgery; dose imaging in radiation therapy; Cherenkov light imaging; image guided spectroscopy of cancer; photodynamic therapy; and modeling of tumor pathophysiology and contrast.

Srivalleesha (Valli) Mallidi, PhD

Visiting Scientist
 
Srivaleesha Mallidi is an Assistant professor at Tuft University.  Prior to Tufts, Dr. Mallidi was Assistant Professor at the Wellman Center for Photomedicine, Harvard Medical School and maintains an affiliate position with MGH and Wellman to continue her research collaborations within the center.  
 
Valli’s research in the Hasan group focuses on photodynamic therapy of glioblastoma, molecular imaging, monitoring therapy and on developing low cost PDT strategies. She now directs the integrated Biofunctional imaging and therapeutics lab  (iBIT Lab) in the Department of Biomedical Engineering, Tufts University . 

Huang-Chiao (Joe) Huang, PhD

Visiting Scientist
 
Joe Huang is an Associate Professor at the University of Maryland, Fischell Department of Bioengineering. His research focuses on integrating nanoscience and photobiology to help fight disease and improve human health. 

 

All led by: 

 

 

 

Dr. Tayyaba Hasan PhD

Principal Investigator